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Shailesh Shahi, PhD

Instructor (Junior Faculty)

Introduction

I am a neuro-immunologist with a particular interest in elucidating the role of gut microbiota in autoimmune inflammatory demyelinating disease of central nervous system.

Current projects include:

  • The role of obesity and gut microbiota in severity of autoimmune demyelinating disease (multiple sclerosis-MS)

  • Mechanism by which interleukin 17 regulates demyelinating disease

  • Determine the immunomodulatory and disease suppressive role of gut microbiota that can possibly provide a new strategy for treatment of autoimmune inflammatory demyelinating disease

Current Positions

  • Instructor (Junior Faculty)

Education

  • BS Honors Degree in Biology, Magadh University, India
  • M.S. in Biotechnology, Banaras Hindu University, India
  • PhD in Biotechnology, Banaras Hindu University, India
  • Postdoctoral Fellow, Department of Pathology, University of Iowa, USA
  • Assistant Research Scientist, Department of Pathology, University of Iowa, USA

Center, Program and Institute Affiliations

Selected Publications

  • Shahi SK*, Ghimire S, Lehman P, and Mangalam AK* (2022). Obesity induced gut dysbiosis contribute to disease severity in the animal model of multiple sclerosis. Frontier in Immunology. DOI: 10.3389/fimmu.2022.966417. (*Co-corresponding author). PMID: 36164343
  • Sugiura A, Andrejeva G, Voss K, Heintzman RD, Beier KL, Wolf MM, Greenwood D, Ye X, Shahi SK, Freedman SN, Cameron AM, Foerch P, Bourne T, Xu X, Garcia-Canaveras JC, Mangalam AK, Rabinowitz JD, Rathmell JC. (2022) MTHFD2 is a Metabolic Checkpoint Controlling Effector and Regulatory T Cell Fate and Function. Immunity 2022 Jan 11;55(1):65-81.e9. doi: 10.1016/j.immuni.2021.10.011. Epub 2021 Nov 11. PMID: 34767747.
  • Shahi SK, Ali S, Jaime CM, Guseva NV, Mangalam AK. HLA Class II Polymorphisms Modulate Gut Microbiota and Experimental Autoimmune Encephalomyelitis Phenotype. Immunohorizons. 2021 Aug 11;5(8):627-646. doi: 10.4049/immunohorizons.2100024. PMID: 34380664.
  • Jensen SN, Cady NM, Shahi SK, Peterson SR, Gupta A, Gibson-Corley KN, Mangalam AK. (2021) Isoflavone diet ameliorates experimental autoimmune encephalomyelitis through modulation of gut bacteria depleted in patients with multiple sclerosis. Science Advance. 2021 Jul;7(28). doi: 10.1126/sciadv.abd4595. PMID: 34244137.
  • Shahi SK, Jensen SN, Murra AC, Tang N, Guo H, Gibson-Corley KN, Zhang J, Karandikar NJ, Murray JA, Mangalam AK. (2020) Human Commensal Prevotella histicola Ameliorates Disease as Effectively as Interferon-Beta in the Experimental Autoimmune Encephalomyelitis. Frontiers in Immunology. 11:578648. doi: 10.3389/fimmu.2020. 578648. eCollection 2020.  PMID: 33362764.
  • Shahi SK, Freedman SN, Dahl RA, Karandikar NJ, Mangalam AK. (2019) Scoring disease in an animal model of multiple sclerosis using a novel infrared-based automated activity-monitoring system. Scientific Reports. Dec 16;9(1):19194. doi: 10.1038/s41598-019-55713-7.  PMID: 31844134.
  • Mangalam A, Shahi SK, Luckey D, Karau M, Marietta E, Luo N, Choung RS, Ju J, Sompallae R, Gibson-Corley K, Patel R, Rodriguez M, David C, Taneja V, Murray J. Human Gut-Derived Commensal Bacteria Suppress CNS Inflammatory and Demyelinating Disease. Cell Reports. Aug 8;20(6):1269-1277. doi: 10.1016/j.celrep.2017.07.031.  PMID: 28793252.
  • Shahi SK, Freedman SN, Mangalam AK. Gut microbiome in multiple sclerosis: The players involved and the roles they play. Gut Microbes. 2017 Nov 2;8(6):607-615. doi: 10.1080/19490976.2017.1349041. PMID: 28696139.
  • Aggarwal N, Deerhake ME, DiPalma D, Shahi SK, Gaggioli MR, Mangalam AK, Shinohara ML. Secreted osteopontin from CD4+ T cells limits acute graft-versus-host disease. Cell Reports. 2021 Dec 28;37(13):110170. doi: 10.1016/j.celrep.2021. 110170. PubMed PMID: 34965439.
  • Shahi SK, Zarei K, Guseva NV, Mangalam AK. (2019) Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing. The Journal of Visualized Experiments. Oct 15;(152). doi: 10.3791/59980. PMID: 31680682.