Featured this week: 

• Andrew Bellizzi, MD
• Dustin Bosch MD, PhD
• Marco Hefti, MD
• Anand Rajan KD, MBBS

• Neocortical tau burden determines the degree of cognitive impairment in individuals with Braak stage V neurofibrillary degeneration. Richardson TE, Cherry J, Kandoi S, Rohde SK, Uretsky M, Tuz-Zahra F, Bieniek KF, Farrell K, Hefti MM, Miller MB, Tripodis Y, Stein TD, Maldonado-Díaz C, Hiya S, Beach TG, Corrada MM, Dugger BN, Flanagan ME, Frosch MP, Gearing M, Grinberg LT, Hansen LA, Hawes D, Head E, Keene CD, Kofler J, Lee EB, Nelson PT, Oakley DH, Perrin RJ, Rissman RA, Salamat S, Schneider JA, Serrano GE, Teich AF, Troncoso JC, Wisniewski T, Woltjer RL, Crary JF, Dickson DW, McKee AC, Walker JM. Acta Neuropathol. 2026 May 25;151(1):61. doi: 10.1007/s00401-026-03031-4. PMID: 42184025
   

• Metagenomic polymorphic toxin effector and immunity profiling predicts microbiome development and disease-related dysbiosis. Schroer HW, Beghini F, Raygoza Garay JA, Christakis NA, Bosch DE. mSystems. 2026 May 22:e0030526. doi: 10.1128/msystems.00305-26. Online ahead of print. PMID: 42171373
   

• SMARCA4-deficient undifferentiated tumor in the oral cavity: a rare case report and review of the literature. Tikkhanarak K, Dorris S, Saepoo J, Handoo N, Timmons S, Hellstein J, Kd AR, Otte L, Lanzel E. Oral Surg Oral Med Oral Pathol Oral Radiol. 2026 Apr 27:S2212-4403(26)00155-0. doi: 10.1016/j.oooo.2026.04.019. Online ahead of print. PMID: 42168048
   

• Multiomic analyses delineate human neuroendocrine tumor cell states in relation to normal enteroendocrine cell ontogeny. Singh PN, Hadj Bachir E, Howe JR, Bellizzi AM, Cejas P, Madha-Krause S, Epstein CB, Chan J, Bernstein BE, Kulke MH, Zhou Q, Shivdasani RA. J Clin Invest. 2026 May 21:e197772. doi: 10.1172/JCI197772. Online ahead of print. PMID: 42166365